Angelo D'Alessandro Selected Research

Succinic Acid (Succinate)

12/2022	Succinate Activation of SUCNR1 Predisposes Severely Injured Patients to Neutrophil-mediated ARDS.
1/2021	Red Blood Cell Metabolism in Pyruvate Kinase Deficient Patients.
10/2019	Metabolic impact of red blood cell exchange with rejuvenated red blood cells in sickle cell patients.
1/2019	Selective organ ischaemia/reperfusion identifies liver as the key driver of the post-injury plasma metabolome derangements.
1/2019	Red Blood Cell Metabolic Responses to Torpor and Arousal in the Hibernator Arctic Ground Squirrel.
12/2018	Effects of red blood cell (RBC) transfusion on sickle cell disease recipient plasma and RBC metabolism.
1/2018	All animals are equal but some animals are more equal than others: Plasma lactate and succinate in hemorrhagic shock-A comparison in rodents, swine, nonhuman primates, and injured patients.
7/2017	Red blood cells in hemorrhagic shock: a critical role for glutaminolysis in fueling alanine transamination in rats.
1/2017	Comfortably Numb and Back: Plasma Metabolomics Reveals Biochemical Adaptations in the Hibernating 13-Lined Ground Squirrel.
12/2016	Glutamine metabolism drives succinate accumulation in plasma and the lung during hemorrhagic shock.

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Angelo D'Alessandro Research Topics

Disease

29	Neoplasms (Cancer) 04/2022 - 11/2011
27	Hypoxia (Hypoxemia) 01/2022 - 01/2016
25	Inflammation (Inflammations) 01/2022 - 03/2010
20	Hemolysis 02/2022 - 01/2016
13	Infections 01/2022 - 01/2012
12	COVID-19 01/2022 - 01/2020
12	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 12/2021 - 10/2016
11	Wounds and Injuries (Trauma) 12/2022 - 12/2014
11	Leukemia 12/2021 - 11/2018
11	Hemorrhagic Shock 01/2020 - 12/2014
8	Shock 01/2022 - 05/2015
7	Sickle Cell Anemia (Hemoglobin S Disease) 01/2022 - 01/2017
6	Obesity 01/2022 - 12/2018
6	Glucosephosphate Dehydrogenase Deficiency 01/2021 - 01/2017
6	Hemorrhage 01/2019 - 05/2015
5	Breast Neoplasms (Breast Cancer) 01/2022 - 11/2015
5	Insulin Resistance 01/2022 - 06/2016
5	Pulmonary Hypertension 11/2021 - 10/2016
4	Hypertension (High Blood Pressure) 01/2022 - 10/2019
4	Pancreatic Neoplasms (Pancreatic Cancer) 01/2022 - 09/2011
4	beta-Thalassemia (Cooley's Anemia) 01/2022 - 03/2021
3	Non-alcoholic Fatty Liver Disease 05/2022 - 12/2018
3	Chronic Renal Insufficiency 01/2022 - 01/2020
3	Cholestasis 01/2022 - 11/2018
3	Anemia 12/2021 - 01/2021
3	Disease Progression 01/2021 - 11/2017
3	Ischemia 01/2019 - 06/2014
2	Multiple Organ Failure (MODS) 11/2022 - 12/2014
2	Neuroblastoma 10/2022 - 01/2021
2	Melanoma (Melanoma, Malignant) 04/2022 - 01/2021
2	Carcinogenesis 04/2022 - 01/2019
2	Adenocarcinoma 01/2022 - 12/2019
2	Intestinal Failure 01/2022 - 12/2021

Drug/Important Bio-Agent (IBA)

19	Proteins (Proteins, Gene)FDA Link 01/2022 - 06/2014
18	Amino Acids FDA Link 05/2022 - 06/2015
14	CytokinesIBA 11/2022 - 10/2016
13	Fatty Acids (Saturated Fatty Acids)IBA 05/2022 - 09/2011
13	Oxygen (Dioxygen)IBA 01/2022 - 01/2016
13	EnzymesIBA 01/2021 - 09/2011
11	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 08/2015
10	Succinic Acid (Succinate)IBA 12/2022 - 12/2016
10	LipidsIBA 05/2022 - 06/2014
10	purineIBA 02/2022 - 06/2014
10	Lactic Acid (Lactate)FDA LinkGeneric 01/2021 - 06/2014
9	Glutathione (Reduced Glutathione)IBA 01/2021 - 06/2014
8	Oxidants (Oxidizing Agents)IBA 10/2021 - 01/2016
8	Choline (Choline Chloride)IBA 01/2021 - 01/2019
8	CarbonIBA 01/2021 - 04/2015
7	NitrogenIBA 03/2021 - 04/2015
7	C-Reactive ProteinIBA 03/2021 - 01/2019
7	Hemoglobins (Hemoglobin)IBA 11/2020 - 01/2016
6	Carboxylic AcidsIBA 05/2022 - 08/2015
6	Pharmaceutical PreparationsIBA 01/2021 - 01/2012
5	AntioxidantsIBA 05/2022 - 06/2014
5	HypoxanthineIBA 02/2022 - 01/2018
5	IronIBA 12/2021 - 01/2019
5	ProteomeIBA 09/2021 - 12/2014
5	NADP (NADPH)IBA 01/2021 - 09/2011
5	sphingosine 1-phosphate (sphingosine-1-phosphate)IBA 01/2021 - 01/2016
5	venetoclaxIBA 12/2020 - 12/2018
5	KynurenineIBA 05/2020 - 11/2015
5	Biomarkers (Surrogate Marker)IBA 12/2019 - 01/2016
5	Glutamine (L-Glutamine)FDA Link 01/2019 - 01/2016
4	Complement System Proteins (Complement)IBA 11/2022 - 01/2019
4	Carnitine (L-Carnitine)FDA LinkGeneric 01/2022 - 11/2020
4	RNA (Ribonucleic Acid)IBA 01/2022 - 01/2020
4	Bile Acids and Salts (Bile Acids)IBA 01/2022 - 05/2015
4	Biological ProductsIBA 05/2021 - 11/2011
4	SerpinsIBA 03/2021 - 03/2010
4	CollagenIBA 01/2021 - 01/2017
4	Urea (Carbamide)FDA LinkGeneric 01/2021 - 01/2020
4	IsotopesIBA 01/2021 - 12/2016
4	Glucosephosphate Dehydrogenase (Glucose 6 Phosphate Dehydrogenase)IBA 01/2021 - 11/2018
4	Tryptophan (L-Tryptophan)FDA Link 05/2020 - 01/2019
4	2,3-Diphosphoglycerate (2,3 Bisphosphoglycerate)IBA 01/2020 - 10/2016
3	AMP-Activated Protein KinasesIBA 10/2022 - 08/2016
3	PhosphatidylserinesIBA 02/2022 - 12/2021
3	Nucleic AcidsIBA 01/2022 - 01/2020
3	Adenosine Triphosphate (ATP)IBA 01/2022 - 01/2019
3	Tyrosine Kinase InhibitorsIBA 12/2021 - 07/2018
3	Pyruvate KinaseIBA 11/2021 - 12/2017
3	InflammasomesIBA 01/2021 - 01/2018
3	dapansutrileIBA 01/2021 - 01/2018
3	Azacitidine (5 Azacytidine)FDA Link 12/2020 - 12/2018
3	Reactive Oxygen Species (Oxygen Radicals)IBA 11/2020 - 12/2016
3	Phosphates (Orthophosphate)IBA 11/2020 - 01/2018
3	Interleukin-6 (Interleukin 6)IBA 11/2020 - 01/2020
3	deoxyhemoglobinIBA 11/2020 - 10/2016
3	Adenosine (Adenocard)FDA LinkGeneric 01/2020 - 08/2016
3	Pyruvic Acid (Pyruvate)IBA 01/2020 - 07/2017
3	Oxidoreductases (Dehydrogenase)IBA 01/2020 - 01/2016
3	Uric Acid (Urate)IBA 01/2018 - 06/2015
2	FumaratesIBA 12/2022 - 01/2017
2	PQQ Cofactor (Pyrroloquinoline Quinone)IBA 05/2022 - 01/2018
2	SphingomyelinsIBA 04/2022 - 01/2018

Therapy/Procedure

18	Therapeutics 05/2022 - 08/2016
8	Resuscitation 11/2022 - 05/2015
6	Drug Therapy (Chemotherapy) 01/2021 - 01/2018
3	Parenteral Nutrition 01/2022 - 11/2018
3	Precision Medicine 12/2020 - 01/2017